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Home  Research Areas The Multiphase Optimization Strategy Learn More
We are working on MOST all the time, so watch this web site for updates. In the meantime, here is a list of articles for those interested in learning more.
These two articles were the first to present the MOST approach. We have been working on expanding the MOST framework and making the steps more explicit, so these articles are a bit dated, but they introduce the basic concepts:
Collins, L.M., Murphy, S.A., Nair, V., & Strecher, V. (2005). A strategy for optimizing and evaluating behavioral interventions. Annals of Behavioral Medicine, 30, 65-73.
Collins, L.M., Murphy, S.A., & Strecher, V. (2007). The Multiphase Optimization Strategy (MOST) and the Sequential Multiple Assignment Randomized Trial (SMART): New methods for more potent e-health interventions. American Journal of Preventive Medicine, 32, S112-S118.
This article reports on the use of a fractional factorial screening experiment to develop an optimized smoking cessation intervention:
Strecher, V.J., McClure, J.B., Alexander, G.W., Chakraborty, B., Nair, V.N., Konkel, J.M., Greene, S.M., Collins, L.M., Carlier, C.C., Wiese, C.J., Little, R.J., Pomerleau, C.S., Pomerleau, O.F. (2008). Web-based smoking cessation programs: Results of a randomized trial. American Journal of Preventive Medicine, 34, 373-381.
This article uses a simulation to explore the circumstances under which an investigator might wish to use a phased optimization approach rather than a single RCT to build a more potent behavioral intervention:
Collins, L.M., Chakraborty, B., Murphy, S.A., & Strecher, V. (2009). Comparison of a phased experimental approach and a single randomized clinical trial for developing multicomponent behavioral interventions. Clinical Trials, 6, 5-15.
This article reviews the use of several different kinds of experimental designs available to behavioral scientists, including factorial and fractional factorial designs, and offers a framework for choosing which is best in any given situation:
Collins, L.M., Dziak, J.R., & Li, R. (In press). Design of experiments with multiple independent variables: A resource management perspective on complete and reduced factorial designs. Psychological Methods.
This article discusses some common misconceptions about the use of fractional factorial experimental designs in medical research:
Chakraborty, B., Collins, L.M., Strecher, V., and Murphy, S.A. (In press). Developing multicomponent interventions using fractional factorial designs. Statistics in Medicine.
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