Principal Investigator, The Methodology Center
H.E. Robbins Professor, Statistics
Research Professor, The Institute for Social Research
Department of Statistics
439 West Hall, 1085 S. Univ.
University of Michigan
Ann Arbor, MI 48109-1107
Ph.D., University of North Carolina, 1989 (Statistics)
B.S., Louisiana State University, 1980 (Mathematics)
Research Interests & Collaborations
I am working on multiple related projects all aimed at how best to collect and use data in the development of adaptive interventions. My collaborators on these projects are Daniel Almirall, Linda Collins, and Inbal Nahum-Shani.
My current primary interest concerns clinical trial design and the development of data analytic methods for informing multi-stage decision making in health. In particular for (1) constructing individualized sequences of treatments (known as adaptive interventions) for use in informing clinical decision making and (2) constructing real-time individualized sequences of treatments (known as just-in-time adaptive interventions) delivered by mobile devices. (See workshop on just in time adaptive interventions.) Adaptive Interventions, also known as dynamic treatment regimes, are composed of a sequence of decision rules that specify when to alter the therapy and specify which intensity or type of subsequent therapy should be offered. The decision rules employ variables such as patient response, risk, burden, adherence, and preference, collected during prior therapy. These regimes hold the promise of maximizing treatment efficacy by avoiding ill effects due to over-treatment and by providing increased treatment levels to those who can benefit. My work has been funded by the National Institute on Drug Abuse and the National Institute of Mental Health.
Recent Honors & Awards
2014: Elected a Member of the Institute of Medicine
2014: Elected a Fellow of the College of Problems of Drug Dependence
2013: MacArthur Fellowship
2011: Elected a Member of the International Statistical Institute.
Bekiroglu, K., Lagoa, C., Murphy, S., & Lanza, S. T. (in press). A robust MPC approach to the design of treatments. Proceedings of the 52nd IEEE Conference on Decision and Control.
Almirall, D., Griffin, B. A., McCaffrey, D. F., Ramchand, R., Yuen, R. A., & Murphy, S. (2014). Time-varying effect moderation using the structural nested mean model: Estimation using inverse-weighted regression with residuals. Statistics in Medicine, 33, 3466-3487.
Almirall, D., Nahum-Shani, I., Sherwood, N. E., & Murphy, S. A. (2014). Introduction to SMART designs for the development of adaptive interventions: With application to weight loss research. Translational Behavioral Medicine, 43, 260-274.
Chakraborty, B., & Murphy, S. A. (2014). Dynamic treatment regimes. Annual Review of Statistics and its Application, 1, 447-464.
Laber, E.B., Lizotte, D.J., Qian, M., Pelham, W.E., & Murphy, S.A. (2014). Dynamic treatment regimes: Technical challenges and applications. Electron J Stat, 8(1), 1225-1272.
Lagoa, C., Bekiroglu, K., Lanza, S. T., & Murphy, S. (2014). Designing adaptive intensive interventions using methods from engineering. Journal of Consulting and Clinical Psychology, 82, 868-878.
Shortreed, S. M., Laber, E., Stroup, T. S., Pineau, J., & Murphy, S. A. (2014). A multiple imputation strategy for sequential multiple assignment randomized trials. Statistics in Medicine, 33(24), 4202-14.
Almirall, D., Griffin, B. A., McCaffrey, D. F., Ramchand, R., Yuen, R. A., & Murphy, S. A. (2013). Time-varying effect moderation using the structural nested mean model: Estimation using inverse-weighted regression with residuals. Statistics in Medicine. Advance online publication. doi: 10.1002/sim.5892
Kumar, S., Nilsen, W.J., Abernethy, A., Atienza, A., Patrick, K., Pavel, M., Riley, W. T., Shar, A., Spring, B., Spruijt-Metz, D., Hedeker, D., Honavar, V., Kravitz, R., Craig Lefebvre, R., Mohr, D.C., Murphy, S.A., Quinn, C., Shusterman, V., Swendeman, D. (2013). Mobile health technology evaluation, the mHealth evidence workshop. American Journal of Preventive Medicine, 45(2), 228-236. PMC Journal-In Process
Nahum-Shani, I., Xi, L., Henderson, M. M., & Murphy, S. A. (2013). An innovative experimental design for addressing the “assistance dilemma” using interactive learning environments. In S. A. Karabenick & M. Puustinen (Eds), Advances in help-seeking research and applications: The role of emerging technologies. Charlotte, NC: Information Age Publishing.
Qian, M., Nahum-Shani, I., Murphy, S. A. (2013). Dynamic treatment regimes. In X. Tu and W. Tang (Eds.), Modern clinical trial analysis. New York, NY: Springer Science.