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Home  Research Areas Adaptive Treatment Strategies Bibliography
Introduction of Adaptive Treatment Strategies
Murphy, S.A. & McKay, J.R., (2004). Adaptive Treatment Strategies: an Emerging Approach for Improving Treatment Effectiveness. Clinical Science (Newsletter of the American Psychological Association Division 12, section III: The Society for the Science of Clinical Psychology). Winter 2003/Spring 2004.
Murphy, S.A., Collins, L.M. & Rush, A.J., (2007). Customizing Treatment to the Patient: Adaptive Treatment Strategies (Editorial). Drug and Alcohol Dependence, 88(2), S1-S72.
Murphy, S.A. & Almirall, D., (2008). Dynamic Treatment Regimes, To appear in the Encyclopedia of Medical Decision Making.
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Experimental Methods for Developing Adaptive Treatment Strategies
Collins, L.M., Murphy, S.A., Nair, V. & Strecher, V., (2004). A Strategy for Optimizing and Evaluating Behavioral Interventions. Annals of Behavioral Medicine, 30, 65-73.
Dawson, R., Lavori, P.W. & W.H., (1999). Course of Treatment Received by Depressed Patients. Coryell, J. Endicott, and M.B. Keller Journal of Psychiatric Research, 33, 233-242.
Dawson, R. & Lavori, P.W., (2003). Comparison of Designs for Adaptive Treatment Strategies: Baseline vs. Adaptive Randomization. Journal of Statistical Planning and Inference, 117(2), 365-385.
Dawson, R. & Lavori, P.W., (2004). Placebo-free Designs for Evaluating New Mental Health Treatments: The Use of Adaptive Treatment Strategies. Statistics in Medicine, 23(21), 3249-3262.
Lavori, P.W. & Dawson, R., (2004). Dynamic Treatment Regimes: Practical Design Considerations. Clinical Trials, 1(1), 12:9-20.
Lavori, P.W. & Dawson, R., (2000). A design for testing clinical strategies: biased individually tailored within-subject randomization. Journal of the Royal Statistical Society A, 163, 29-38.
Murphy, S.A., (2005). An Experimental Design for the Development of Adaptive Treatment Strategies. Statistics in Medicine, 24(10), 1455–1481.
Murphy, S.A., Lynch, K.G., McKay, J.R., Oslin, D., & TenHave, T., (2007). Developing Adaptive Treatment Strategies in Substance Abuse Research. Drug and Alcohol Dependence, 88(2), S24-S30.
Murphy, S.A. & Bingham, D., (2008). Screening Experiments for Developing Dynamic Treatment Regimes. To Appear in JASA.
Oetting, A.I., Levy, J.A., Weiss, R.D. & Murphy, S.A., (2007). Statistical Methodology for a SMART Design in the Development of Adaptive Treatment Strategies. To appear in Causality and Psychopathology: Finding the Determinants of Disorders and their Cures (P.E. Shrout, Ed.) Arlington VA, American Psychiatric Publishing, Inc.
TenHave, T., Coyne, J., Salzer, M. & Katz, I., (2003). Research to improve the quality of care for depression: alternatives to the simple randomized clinical trial. General Hospital Psychiatry, 25, 115-123.
Thall, P.F., Sung, H.G. & Estey, E.H., (2002). Selecting Therapeutic Strategies Based on Efficacy and Death in Multi-Course Clinical Trials. Journal of the American Statistical Association, 97(457), 29-39.
Thall, P.F. & Wathen, J.K., (2005). Covariate-adjusted adaptive randomization in a sarcoma trial with multi-stage treatments. Statistics in Medicine, 24, 1947-1964.
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How to Use Clinical Experience, Theory, etc. to Form Adaptive Treatment Strategies
Brooner, R.K. & Kidorf, M., (2002). Using Behavioral Reinforcement to Improve Methadone Treatment Participation. Science and Practice Perspectives, 1, 38-48.
Collins, L.M., Murphy, S.A. & Bierman, K., (2004). A Conceptual Framework for Adaptive Preventive Interventions. Prevention Science, 5(3), 185-196.
McLellan, A.T., (2002). Have we Evaluated Addiction Treatment Correctly? Implications from a Chronic Care Perspective. Society for the Study of Addiction to Alcohol and Other Drugs, 97, 249-252.
McLellan, A.T., Lewis, D.C., O'Brien, C.P. & Kleber, H.D., (2000). Drug Dependence, a Chronic Medical Illness-Implications for treatment, insurance, and outcomes evaluation. Journal of the American Medical Association, 284(13), 1689-1695.
Sachs, G.S., (2004). Strategies for Improving Treatment of Bipolar Disorder: Integration of Measurement and Management. Acta Psychiatrica Scandinavica, 110(Suppl 422), 7-17.
Sobell, M.B. & Sobell, L.C., (2000). Stepped Care as a Heuristic Approach to the Treatment of Alcohol Problems. Journal of Consulting and Clinical Psychology, 68(4), 573-579.
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Statistical Methods for the Construction of Adaptive Treatment Strategies
Blatt, D., Murphy, S.A., & Zhu, J., (2004). A-learning for Approximate Planning. (Tech. Rep. No. 04-63). University Park, PA: The Methodology Center, The Pennsylvania State University.
Lunceford, J.K., Davidian, M. & Tsiatis, A.A., (2002). Estimation of survival distributions of treatment policies in two-stage randomization designs in clinical trials. Biometrics, 58, 48-57.
Moodie, E.E., Richardson, T.S. & Stephens, D.A., (2005). Demystifying Optimal Dynamic Treatment Regimes. UW Biostatistics Working Paper Series.
Murphy, S.A., Van Der Laan, M.J., J.M. and C.P.P.R.G., (2001). Marginal Mean Models for Dynamic Regimes. Journal of the American Statistical Association, 96, 1410-1423.
Murphy, S.A., (2003). Optimal Dynamic Treatment Regimes. Journal of the Royal Statistical Society, Series B, 65(2), 331-366.
Murphy, S.A., (2005). A Generalization Error for Q-Learning, Journal of Machine Learning Research. 6(Jul), 1073-1097.
Sutton, R.S. & Barto, A.G., (1998). Reinforcement Learning: An Introduction. Cambridge, Mass: The MIT Press.
Thall, P.F., Millikan, R.E. & Sung, H.G., (2000). Evaluating Multiple Treatment Courses in Clinical Trials. Statistics in Medicine, 19, 1011-1028.
Thall, P.F., Sung, H.G. & Estey, E.H., (2002). Selecting Therapeutic Strategies Based on Efficacy and Death in Multi-Course Clinical Trials. Journal of the American Statistical Association, 97(457), 29-39.
Thall, P.F., Wooten, L.H., Logothetis, C.J., Millikan, R. & Tannir, N.M., (2007). Bayesian and frequentist two-stage treatment strategies based on sequential failure times subject to interval censoring. Statistics in Medicine, 26, 4687-4702.
Robins, J.M., (1986). A new approach to causal inference in mortality studies with sustained exposure periods -application to control of the healthy worker survivor effect. Computers and Mathematicswith Applications, 14, 1393-1512.
Robins, J.M., (2004). Optimal Structural Nested Models for Optimal Sequential Decisions. In Lin D.Y. and Heagerty P.J. (Eds.), Proceedings of the Second Seattle Symposium on Biostatistics (pp. 189-326), New York, Springer.
Wahed, A.S. & Tsiatis, A.A., (2004). Optimal estimator for the survival distribution and related quantities for treatment policies in two-stage randomization designs in clinical trials. Biometrics, 60, 124-133.
Wahed, A.S. & Tsiatis, A.A., (2006). Semiparametric efficient estimation of survival distribution for treatment policies in two-stage randomization designs in clinical trials with censored data. Biometrika, 93, 163-177.
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Inference and Other Analyses Concerning Adaptive Treatment Strategies
Chakraborty, B. & Murphy, S.A., (2009). Inference for Nonregular Parameters in Optimal Dynamic Treatment Regimes . To appear in the special issue on "Clinical Trials in Mental Health" of the journal "Statistical Methods in Medical Research".
Gunter, L., Zhu, J. & Murphy, S.A., (2008). Variable Selection for Qualititative Interactions. Submitted.
Lizotte, D.J., Laber, E. & Murphy, S.A., (2009). Assessing confidence in policies learned from sequential randomized trials. Submitted.
Moodie, E.E. & Richardson, T.S., (2007). Bias correction in non-differentiable estimating equations for optimal dynamic regimes. COBRA Preprint Series. Article 17.
Robins, J.M., (2004). Optimal Structural Nested Models for Optimal Sequential Decisions. In: Lin D.Y. and Heagerty P.J. (Eds.), Proceedings of the Second Seattle Symposium on Biostatistics (pp. 189-326), New York: Springer.
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